Essay On Hepatitis C

Essay On Hepatitis C-3
Since 1992, however, the screening of donated blood for HCV antibody sharply reduced the risk of transfusion-associated HCV infection.

Tags: Essay Education System SchoolFive Paragraph Research Essay OutlineVirginia Woolf Essays On WritingEssay Writing ReviewTok Essay FormatWriting A Visual Analysis EssayStudy Research Objective EssayResearch Paper Writing Skills

Most patients with acute and chronic infection are asymptomatic.

Patients and healthcare providers may detect no indications of these conditions for long periods; however, chronic hepatitis C infection and chronic active hepatitis are slowly progressive diseases and result in severe morbidity in 20-30% of infected persons.

These represent minor molecular variations with only 1%-2% nucleotide heterogeneity.

HCV quasispecies pose a major challenge to immune-mediated control of HCV and may explain the variable clinical course and the difficulties in vaccine development.

Two regions of the E2 protein, designated hypervariable regions 1 and 2, have an extremely high rate of mutation, believed to result from selective pressure by virus-specific antibodies.

The envelope protein E2 also contains the binding site for CD-81, a tetraspanin receptor expressed on hepatocytes and B lymphocytes that acts as a receptor or coreceptor for HCV.

The major HCV genotype worldwide is genotype 1, which accounts for 40%-80% of all isolates.

Genotype 1 also may be associated with more severe liver disease and a higher risk of hepatocellular carcinoma.

NS5A is critical for the assembly of the cytoplasmic membrane-bound replication complex; one region within NS5A is linked to an interferon (IFN) response and is called the IFN sensitivity–determining region.

NS5B is an RNA dependent RNA polymerase required for viral replication; it lacks proofreading capabilities and generates a large number of mutant viruses known as quasispecies.

SHOW COMMENTS

Comments Essay On Hepatitis C

The Latest from mastan.ru ©