Hematology Case Studies Anemia

Hematology Case Studies Anemia-85
Reticulocyte Count This test provides information on the number of relatively immature red blood cells in a person's blood sample. (February 2009) National Heart, Lung, Blood Institute: Hemolytic anemia. When someone has anemia (low RBC count, hemoglobin, and hematocrit), the results of this test can help determine the cause and/or help classify the type of anemia. (February 2009) National Heart, Lung, Blood Institute: Aplastic anemia. The patient's findings were thought to be consistent with idiopathic thrombocytopenic purpura.

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Additional history of an "abnormal hemoglobin" in one parent was obtained.

HEMOGLOBIN ELECTROPHORESIS: Graphic representation (Figure 13) of the hemoglobin electrophoresis of the patient's blood on cellulose acetate at p H 8.5 demonstrates 25.9% Hb A1, 21.1% Hb F, and 53% "other" Hb, which migrates with the Hb C group (Table 1).

Anemia can be mild, moderate, or severe depending on how much the RBC count and/or hemoglobin levels are decreased.

In general, the main causes of anemia include: Anemia may be acute or chronic.

The presence of anemia in chronic conditions may often go undetected for a period of time and sometimes may only be discovered during tests or examinations for other conditions.

Anemia may also occur in acute episodes such as with substantial blood loss (extensive injury or invasive surgery) or with certain anemias in which a significant number of RBCs are destroyed known as hemolytic anemia. Blood Smear and Differential If results of the CBC indicate anemia, it may be followed up with an examination of a blood smear or a differential, which counts white blood cells. (February 2009) National Heart, Lung, Blood Institute: Iron deficiency anemia. The smear review can provide additional information, such as the shape of red blood cells and the presence of abnormal cells, which can help diagnose and classify anemia. (February 2009) National Heart, Lung, Blood Institute: Sickle Cell anemia, diagnosis. People with anemia may experience fatigue and weakness and may lack energy. Anemia is a fairly common condition, affecting both men and women of all ages, races, and ethnic groups. Erythroid maturation was megaloblastoid with dyserythropoietic forms.Megakaryocytes were present in moderately increased forms.A picture of the actual cellulose acetate gel (p H 8.5) shows a prominent electro-phoretic band migrating with the hemoglobin C group (arrows, Figure 14, left).A picture of the hemoglobin electrophoresis on a citrate agar gel, p H 6.0 shows the prominent band now migrating with the Hb A group (arrows, Figure 14, right).PATIENT HISTORY: The patient is a three year-old female who presented with a history of thrombocytopenia and nosebleeds and easy bruising for two weeks, clinically thought to be consistent with Idiopathic Thrombocytopenic Purpura.A bone marrow was performed to rule out acute leukemia.


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