Multi-center, double-blind, double-dummy, randomized, placebo- and active-reference, parallel group, Phase 2 dose-finding study with ACT-132577 in subjects with essential hypertension (grade 1 and 2) The primary objective of the study is to explore 4 doses of ACT-132577 on diastolic blood pressure (DBP) in subjects with essential hypertension (grade 1 and 2).Cardio MEMSTM HF System Post Approval Study The Cardio MEMS HF System provides a method to measure pulmonary artery (PA) pressures by using a small wireless sensor (about the size of a paperclip) implanted into the pulmonary artery (a vessel close to your heart).Since hypertension is a leading risk factor for heart attack and stroke, the new study calls into question the notion that moderate alcohol consumption benefits heart health.
They plan to further analyze the data for insights on how demographic factors might influence the relationship between alcohol consumption and high blood pressure.
Aladin will present the study, "Alcohol Consumption and Risk of Hypertension," on Sunday, March 17. "Moderate alcohol consumption linked with high blood pressure: Study among the first to suggest moderate drinking harms, rather than protects, heart health." Science Daily.
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Alcohol's activities in the brain and liver could also contribute to spikes in blood pressure.
Data for the research came from the National Health and Nutrition Examination Study (NHANES), a large, decades-long study led by the Centers for Disease Control and Prevention. Participants reported their drinking behavior on several questionnaires administered by mail and in person.
The pattern among heavy drinkers was even more pronounced; relative to those who never drank, heavy drinkers were 69 percent more likely to have stage 1 hypertension and 2.4 times as likely to have stage 2 hypertension.
Overall, the average blood pressure was about 109/67 mm Hg among never-drinkers, 128/79 mm Hg among moderate drinkers and 153/82 mm Hg among heavy drinkers.
In their analysis, researchers adjusted for age, sex, race, income and cardiovascular risk to separate the effects from alcohol consumption from other factors with known links to hypertension.
Aladin said the study's large sample size likely helps explain why the findings appear to contrast with previous studies in this area.